Establishment and Development:

JDY-Lab was born from a shared vision and passion for burn wound repair and skin-tissue engineering. Recognizing the need for scarless healing of patients, our founders decided to establish a laboratory dedicated to apply the laboratory research results of mesenchymal stem cells（fetal dermal mesenchymal stem cells） and acellular dermal matrix to clinical practice. The journey of JDY-Lab began with the founder of Professor Duyin Jiang was employed by Shandong University in 2007. With a small but dedicated team, we set out to establish a research laboratory that would be recognized for its excellence and impact. Since its inception, JDY-Lab has gone through a remarkable journey of growth and development. We have discovered the involvement of sex hormones and tumor suppressor genes RB and P53 mutations in the keloid formation, and was the first to carry out basic and clinical application research on one-step composite transplantation of allogeneic/xenoacellular acellular dermal matrix(ADM) in China and abroad. At present, our research has evolved to 1) fetal dermal mesenchymal stem cells for the treatment of wounds and anti-skin aging ; 2) Study on the mechanism of aging wound inflammation; 3) Study on the mechanism of keloid; 4) The application of growth factors and ADM in wound treatment.. Additionally, we have forged valuable collaborations and partnerships with collaborators in Ji’nan University to further enhance our research capabilities.

Team Members:

Our team is composed of leading experts in their fields, young and passionate researchers, and support staff dedicated to excellence. Together, they work tirelessly to contribute to the wound healing and anti-aging.

Principal Investigator

Duyin Jiang (姜笃银),Ph.D., M.D.

Chief Physician, Professor, Doctoral Supervisor

86-15153169399

Jdybs2＠vip.163.com

Research:

Professor Jiang focuses on the basic research and application of tissue engineering materials and (denatured) acellular dermal matrix in wound repair.

Staff

Jie Zhao (赵洁), Ph.D., M.D.

Deputy Chief Physician

86-17660083669

4220458387@qq.com

Research:

Basic research and clinical application of wound and burn repair.

Trainee

At present, we have 1 postdoctoral student, 7 doctoral students and 6 master’s Student. Together with the leading experts, these young researchers work hard to achieve the better wound healing.

Research Areas:

JDY-Lab specializes in burn wound repair and skin-tissue engineering. The research directions of the department are: (1) the role of fetal dermal mesenchymal stem cells in skin tissue repair, regeneration and anti-aging; (2) basic research and application of tissue engineering materials and (denatured) acellular dermal matrix in burn wound repair; (3) the study of the biological activity of keloid fibroblasts inhibited by mesenchymal stem cells; (4) the hierarchical management, diagnosis and treatment of acute and chronic wounds and specialized training.

Research Achievements:

We have made significant contributions in chronic wound repair and skin tissue research. We found the relationship between the characteristics of abnormal proliferation and differentiation of epithelial cells and different outcomes of wound (burn) repair in human skin. After that, we find and apart a new mesenchymal stem cell, we called it “fetal dermal mesenchymal stem cell(FDMSC)”. Around this mesenchymal cell, we had performed many researches, and during this period, we prepared a thermal-hydrolyzed protein and a acellular dermal matrix. And we found out these bio-materials have promising usage in many areas. During these years, we have gained 11 invention patents and 3 utility model patents.

Main Publications:

(1) Xiaoyang Wang; Jie Zhao; Xiaochuan Wang; Jingjuan Zhang; Yi Wang; Xinyue Wang; Shanshan Jia; Nian Shi; Meiqi Lu; Hongxia Su; Jixun Zhang; Duyin Jiang; Bacterial cellulose membrane combined with BMSCs promotes wound healing by activating the notch signaling pathway, Frontiers in Surgery, 2023, 9

(2)Xiao Wang; Ya Jiao; Yi Pan; Longxiao Zhang; Hongmin Gong; Yongjun Qi; Maoying Wang; Huiping Gong; Mingju Shao; Xinglei Wang; Duyin Jiang; Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling, Stem Cells International, 2019, 2019: 1-11

(3)Qi Yongjun; Dong Zhengxue; Chu Hongzhen; Zhao Qi; Wang Xiao; Jiao Ya; Gong Hongmin; Pan Yi; Jiang Duyin; Denatured acellular dermal matrix seeded with bone marrow mesenchymal stem cells for wound healing in mice, Burns, 2019, 45(7): 1685-1694

(4)Shengsheng Pan; Siyu Gong; Jingjuan Zhang; Shanshan Jia; Maoying Wang; Yi Pan; Xiao Wang; Duyin Jiang; Anti-aging effects of fetal dermal mesenchymal stem cells in a D-galactose-induced aging model of adult dermal fibroblasts, In Vitro Cellular & Developmental Biology - Animal, 2021, 57(8): 795-807

(5)Yi Pan; Xiao Wang; Xinglei Wang; Fei Shan; Maoying Wang; Jixun Zhang; Jingjuan Zhang; Shanshan Jia; Ya Jiao; Yongjun Qi; Hongmin Gong; Duyin Jiang;Protective Effect of Conditioned Media of Human Fetal Dermal Mesenchymal Stem Cells Can Inhibit Burn-induced Microvascular Hyperpermeability, Journal of Burn Care & Research, 2021, 16(1)

(6)Ji-xun Zhang; Chuan Li; Yao-nan Li; Zheng-xue Dong; Dao-jing Qiu; Du-yin Jiang ; Growth of early or midterm human foetal skin in a burn model:establishment of the model, morphological and histological observations., Biomedical Research, 2017.02, 28(6): 2504-2514

(7)Chao Wang; Ji-xun Zhang; Zhenzhong Liu ; Stool Management Followed by Surgical Debridement and Surgical Closure Combined With Negative Pressure Wound Therapy in the Treatment of Posterior Trunk Pressure Injury: A Retrospective Descriptive Study, Wound management & prevention, 2022, 68(4): 26-33

(8)Chao Wang; Ji-xun Zhang; Zhenzhong Liu ; Vacuum‐assisted closure therapy combined with bi‐pectoral muscle flap for the treatment of deep sternal wound infections, International Wound Journal, 2019, 17(2): 332-338

(9)Ya Jia; Xiao Wang; Ji-xun Zhang; Yongjun Qi; Hongmin Gong; Duyin Jiang ; Inhibiting function of human fetal dermal mesenchymal stem cells on bioactivities of keloid fibroblasts, Stem Cell Research & Therapy, 2017.07, 8(1): 170-178

(10)Xinyue Wang, Jie Zhao, Ya Jiao, Xinglei Wang, Duyin Jiang. Upper gastrointestinal foreign bodies in adults: A systematic review. Am J Emerg Med, 50(2021):136-141.

Facilities & Resources:

Our state-of-the-art facilities and cutting-edge technology enable us to conduct research that is both rigorous and innovative. The research group is located in the Basic Medical Research Institute of the hospital, which has five major research institutions including the Central Laboratory, Experimental Animal Center, Evidence Based Medicine Center, Gene and Immunotherapy Center, and Translational Medicine Research Center. The laboratory covers an area of more than 6000 square meters and has molecular biology experimental platform, cell biology experimental platform, immunology and histopathology experimental platform, microscopic characterization platform, electrophysiology platform, and SPF level experimental animal platform Various experimental platforms such as evidence-based medicine platform and biomedical sample library are equipped with basic and high-end instruments and equipment for studying the structure and function of biomolecules, cell morphology and function, construction and experimentation of animal models, and storage, processing, and analysis of clinical samples.

Collaborations & Partnerships:

We believe in the power of collaboration. That's why we have forged partnerships with professor Guo Rui，from the MOE Key Laboratory of Tumor Molecular Biology in Ji’nan university. And industry partners,like Shandong Huaying Biotechnology Co., Ltd, to further advance our research.

Recreational Activities:

Our research group has a variety of team building activities, spending traditional holidays together and having monthly gatherings. We focus on emotional connections between team members. Activities such as mountain climbing and hiking are also frequently held, since Professor Jiang believes that his students should "civilize their spirit and savage their physique".

Contact:

For more information or inquiries, please contact us at Jdybs2@163.vip.com or visit our website at http://www.qlyxgrad.sdu.edu.cn/jsxx/delcxy/jdy.htm