Establishment and Development:

The Interventional Medicine and Minimally Invasive Oncology Department of the Second Hospital of Shandong University was established in 2002. It has now formed a specialty with its own characteristics and academic style, and has a high reputation both domestically and internationally. It has made outstanding contributions to the development of interventional radiology in the province. In 2013, it was approved to establish the Interventional Oncology Institute at Shandong University. In 2013 and 2017, it obtained the authority to confer master's and doctoral degrees, respectively. The department is the chairman unit of the Comprehensive Interventional Medicine Branch of Shandong Medical Association and the chairman unit of the Comprehensive Interventional Physicians Branch of Shandong Medical Association.

The Interventional Medicine and Minimally Invasive Oncology Department is at the international advanced level and domestic leading level in the field of iodine-125 radioactive seed implantation for the treatment of malignant tumors and gallstones. In China, we have earlier carried out iodine-125 radioactive seed implantation for pancreatic cancer/liver cancer/lung cancer, and accumulated rich clinical experience. In 2019, we will become one of the first six "tumor radioactive seed implantation technology training bases" of the Chinese Medical Doctor Association. We have taken the lead in carrying out percutaneous transhepatic papillary balloon dilation for the treatment of common bile duct stones nationwide, and have conducted multiple multicenter studies.

Team Members:

There are a total of 13 medical, teaching, and research personnel, including 2 chief physicians and 2 deputy chief physicians. Among them, 85% are young and middle-aged people under the age of 45, and 77% are doctoral and master's degree holders. We have one doctoral supervisor and one master's supervisor.

Professor Yuliang Li(lyl.pro@sdu.edu.cn), the leader of the discipline and doctoral supervisor, has multiple stable research directions and has trained 8 doctoral students and 10 master's students.

Professor Bin Liu (gordon0221@sdu.edu.cn), the vice leader of the discipline and master supervisor, has multiple stable research directions and has trained 5 master's students.

Research Areas:

1. The molecular mechanism of Iodine-125 radioactive seeds in cancers.

2. The molecular mechanism of traditional Chinese medicine for gallstones.

Main Publications:

1. Liu B, Ma J, Li S, Li C, Qi H, Nian D, Yin C, Zhu J, Wang C, Jia Y, Jiang T, Lu J, Wang L, Shen D, Hou X, Li D, Zhang Z, Du F, Wu H, Yu T, Li Y.  Percutaneous Transhepatic Papillary Balloon Dilation versus Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stones: A Multicenter Prospective Study. Radiology. 2021 Aug;300(2):470-478. DOI: 10.1148/radiol.2021201115.

2. Li D , Wang W , Liu B ,et al.Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis[J].Cell Death Discovery, 2023, 9(1).DOI:10.1038/s41420-023-01593-w.

3. Chao Chen, Wei Wang, Zhe Yu, Shilin Tian, Yuliang Li, Yongzheng Wang. Combination of computed tomography-guided iodine-125 brachytherapy and bronchial arterial chemoembolization for locally advanced stage III non-small cell lung cancer after failure of concurrent chemoradiotherapy. Lung Cancer. 2020 Jun 20;146:290-296. doi: 10.1016/j.lungcan.2020.06.010.

4. Chen C, Wang W, Wang WJ, Wang YZ, Yu Z, Li YL. Locally advanced pancreatic carcinoma with jaundice: the benefit of a sequential treatment with stenting followed by CT-guided 125 I seeds implantation. Eur Radiol. 2021 Sep;31(9):6500-6510. doi: 10.1007/s00330-021-07764-6.

5. Gao H, Wang WJ, Lv XY, Lu G*, Li YL*. Mechanism of Co(III)-catalyzed annulation of N-chlorobenzamide with styrene and origin of cyclopentadienyl ligand-controlled enantioselectivity. Org. Chem. Front., 2023,10, 1643-1650.

6. Wei Wang, Shi-Lin Tian, Hui Wang, Chun-Chun Shao, Yong-Zheng Wang, Yu-Liang Li. Association of Hepatitis B Virus DNA Level and Follow-up Interval with Hepatocellular Carcinoma Recurrence. JAMA Netw Open. 2020 Apr 1;3(4): e203707. 7. Lei Guo, Jiali Sun, Changjun Wang, Yang Wang, Ya Wang, Dong Li, Yuliang Li. Epirubicin Enhances the Anti-Cancer Effects of Radioactive 125I Seeds in Hepatocellular Carcinoma via Downregulation of the JAK/STAT1 Pathway. Front Oncol. 2022; 12 Front Oncol. doi: 10.3389/fonc.2022.854023

8. Rong, JH, Li, D, Li, YL. Lobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway. Onco Targets Ther. 2021; 14 Onco Targets Ther. doi: 10.2147/OTT.S288012

9. Li, D, Wang, WJ, Wang, YZ, et al. Lobaplatin promotes 125I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway. Cell Death Dis. 2019; 10 Cell Death Dis. doi: 10.1038/s41419-019-1918-1

10. He, GH, Xing, DJ, Jin, D, et al. Scutellarin improves the radiosensitivity of non-small cell lung cancer cells to iodine-125 seeds via downregulating the AKT/mTOR pathway. THORAC CANCER. 2021; 12 THORAC CANCER. doi: 10.1111/1759-7714.14077.

Facilities & Resources:

Our lab has molecular biology experimental platform, cell biology experimental platform, immunology and histopathology experimental platform, microscopic characterization platform, electrophysiology platform, SPF level experimental animal platform, evidence-based medicine platform, biomedical sample library, etc. Covering an area of over 6000 square meters, it has the foundation and high-end equipment for studying the structure and function of biological macromolecules, cell morphology and function, animal model construction and experimentation, as well as clinical sample storage, processing and analysis. It includes flux nucleic acid extraction, automatic cutting system, protein purification preparation system, analytical and sorting flow cytometry analyzer, laser confocal microscope, multispectral scanning microscope, laser micro cutting system, digital PCR instrument, fluorescence quantitative PCR instrument, tissue automatic embedding machine, automatic dehydration machine, paraffin and frozen sectioning machine, patch clamp system, calcium ion imaging system, nanoparticle tracking analyzer, IVIS Spectrum CT small animal live optical imaging system, as well as large precision instruments such as darkroom and cold room, as fluorescence quantitative PCR instrument. Facilities such as laboratory, stem cell culture room, clinical sample library, etc.

Collaborations & Partnerships:

We believe in the power of collaboration.

1. Wei Wang, Advanced Medical Research Institute, Shandong University.

2. Xiangbo Meng, Advanced Medical Research Institute, Shandong University.

3. Zhaojian Liu, Advanced Medical Research Institute, Shandong University.

4. Gang Lu, School of Chemistry and Chemical Engineering, Shandong University.

6. Shujun Fu, School of Mathematics, Shandong University

Contact:

For more information or inquiries, please contact Bin Liu at gordon0221@sdu.edu.cn