Establishment and Development:
The "Visualization and Light-Controlled Regulation Guided Drug Research" innovation team at the School of Pharmaceutical Sciences, Shandong University, relies on the Key Laboratory of Chemical Biology of Natural Products of the Ministry of Education and the State Key Discipline of Medicinal Chemistry for support. Our team focuses on addressing the challenges posed by major diseases such as malignant tumors and neurodegenerative disorders in terms of their occurrence, development, and clinical treatment. Our core objective revolves around the development of precise drugs and diagnostic probes. Anchored in drug and probe design (including pharmaceutical design and chemical biology), chemical synthesis (synthetic medicinal chemistry), and biological characterization (analytical chemistry, pharmacology, and imaging), our aim to innovate drug and probe development and practical applications. The team conducts extensive and in-depth fundamental research aimed at the development and practical application of innovative drugs and probes, aiming to contribute significantly to the field.
Team Members:
Our team is composed of leading experts in their respective fields, each with extensive experience and a track record of excellence. This elite group includes 5 professors and 1 associate professor, all of whom have honed their expertise through years of study and work both domestically and overseas. Dedicated to pushing the boundaries of drug research and innovation, our team is committed to tackling the most pressing challenges in pharmaceutical science. Through collaboration, creativity, and a relentless pursuit of excellence, we aim to drive forward the field of drug research and bring about meaningful advancements in medicine.
Research Areas:
Visualization of Biological Activity: Research focuses on developing various types of probes for visualizing biological processes, including fluorescent probes, bioluminescent probes, chemiluminescent probes, and visual prodrugs.
Molecular Probe Development: This area explores orthogonal reactions in biology, light-controlled and photoaffinity reactions, as well as novel strategies and technologies for targeted protein degradation.
Rational Drug Design and Medicinal Chemistry: Research delves into rational drug design and medicinal chemistry targeting ion channels, GPCRs (G-protein-coupled receptors), Cys-loop receptors, autophagy, and protein-protein interactions.
Discovery and Identification of Drug Targets and Binding Sites: Efforts are made to discover and identify drug targets and binding sites, enhancing the understanding of drug-target interactions.
Development of Novel Organic Synthesis Methods: This research direction focuses on the development of new methods in organic synthesis, paving the way for synthesizing novel drug candidates and molecular probes.
Research Achievements:
We have made significant contributions to the field of drug research and innovation. Through our pioneering work in visualizing biological activity, developing molecular probes, and designing targeted therapies, we have advanced our understanding of disease mechanisms and facilitated the development of novel treatment strategies.
Main Publications:
1. Yang X, Ma G, Zheng S, Qin X, Li X, Du L, Wang Y, Zhou Y, Li MY*. Optical control of CRAC channels using photoswitchable azopyrazoles. J. Am. Chem. Soc. 2020, 142, 9460-70. 2．
2. Dong G, Ye X, Wang S, Li W, Cai R, Du L, Shi X, Li MY*. Au-24 as a Potential Thioredoxin Reductase Inhibitor in Hepatocellular Carcinoma Cells. Pharmacol. Res. 2022, 177,106113
3. Yang X, Li M, Qin X, Tan S, Du L, Ma C, Li MY*. Photophosphatidylserine guides natural killer cells photoimmunotherapy via Tim-3. J. Am. Chem. Soc. 2022, 144, 3863-3874.
4. Liang D, Yu C, Ma Z, Yang X, Li Z, Dong X, Qin X, Du L, Li MY*. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning. Acta Pharm. Sin. B. 2022, 12, 2429-42.
5. Sun Y, Gao Y, Tang C, Dong G, Zhao P, Peng D, Wang T, Du L, Li MY*. Multiple rapid-responsive probes towards hypochlorite detection based on dioxetane luminophore derivatives. J. Pharm. Anal. 2022, 12, 446-52.
6. Ye X, Wang C, Zhang S, Tang Q, Wojtas L, Li MY*, Shi X. Chiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation. Chem.-Eur. J. 2022, 28, e202201018.
7. Zuo Z, Kang T, Hu S, Su W, Gan Y, Miao Z, Zhao H, Feng P, Ke B, Li MY*. A Bioluminescent Probe for Detecting Norepinephrine in Vivo. Anal. Chem. 2022, 94, 6441-6445.
8. Li W, Ma Z, Chen J, Dong G, Du L, Li MY*. Discovery of Environment-Sensitive Fluorescent Ligands of β-Adrenergic Receptors for Cell Imaging and NanoBRET Assay. Anal. Chem. 2022, 94, 7021-7028.
9. Li X, Li MY*. The application of zebrafish patient-derived xenograft tumor models in the development of antitumor agents. Med. Res. Rev. 2023, 43, 212-236.
10 Li Z, Ma S, Zhang L, Zhang S, Ma Z, Du L, Li MY*. Targeted protein degradation induced by HEMTACs based on HSP90. J. Med. Chem. 2023, 66, 1, 733–751
Facilities & Resources:
Our laboratory boasts state-of-the-art facilities and resources essential for cutting-edge drug discovery and development. Equipped with advanced chemical synthesis laboratories, computational modeling tools, and molecular biology facilities, we enable comprehensive research spanning from initial compound design to preclinical evaluation. Additionally, our capabilities encompass cell culture facilities, biochemical assay platforms, and animal research facilities compliant with ethical regulations. Advanced imaging and microscopy systems further enhance our ability to visualize molecular interactions and cellular processes. With collaborative spaces fostering interdisciplinary interactions, our team is poised to drive innovation and translate research findings into tangible therapeutic solutions, ultimately advancing healthcare and improving patient outcomes.
Collaborations & Partnerships:
We have forged partnerships with leading universities, research institutions, and industry partners to further advance our research.
Recreational Activities:
During leisure time, our team enjoys a variety of recreational activities to foster camaraderie and relaxation.
Other Features:
N/A
Contact:
For more information or inquiries, please contact us at mli@sdu.edu.cn or visit our website at https://www.pharm.sdu.edu.cn/info/1058/13354.htm
