Establishment and Development:

The team led by the applicant has been committed to neuroimaging research and embryonic brain development research for a long time, and has undertaken 20 projects of the National Natural Science Foundation of China and provincial and ministerial-level projects, and has published more than 300 papers in journals such as Cerebral Cortex, NeuroImage and Human Brain Mapping, etc. (of which more than 70 papers have been indexed by SCI). He has edited 34 academic books, including "Functional Neuroimaging" and "Clinical Central Nervous Anatomy", and translated the world's most famous anatomical work, "Gesellschaft für Anatomie" (41st edition). In 2018, he won the second prize of Shandong Province Science and Technology Award for the project of "Creation and Promotion of Chinese Digital Standard Brain Atlas". In the past 5 years, he has undertaken 3 projects of the National Natural Science Foundation of China (NSFC), and is currently working on the project of "Pre-natal Development and Visualisation of Structural Brain Network Groups" (No.31771328), which constructs the structural brain networks and brain atlas of the foetus from the mid-pregnancy to the birth, and compares the attributes of the structural network of the brain of the foetus and the newborn, to reveal the mechanism of foetal development. The results have been published in NeuroImage, Frontiers in Neuroscience and other journals.

Team Members:

1.Shuwei Liu is currently a professor at Shandong University, deputy director of the Institute of Brain and Brain-like Science at Shandong University, and director of the Digital Human Research Institute at Shandong University. His research interests include tomographic anatomy, computational neuroscience, neurodevelopment and pathogenesis of neuropsychiatric disorders.

2.Yuchun Tang：Tomographic anatomy, neuroimaging, computational neuroscience

3.Lei Feng：tomographic anatomy and neurodevelopmental research.

4. Wenjuan Zhou：pathogenesis of neurodevelopmental and related diseases

5.Haiwei Meng：imaging in Parkinson's disease and neurodevelopmental areas

6.Feifei Xu：Fetal brain structural and functional imaging studie

7.Fengxia Wu：the treatment and mechanism of Parkinson's disease

8.Zhen Liu：Neuropathy and Pain

Research Areas:

The digital human body, digital brain mapping and foetal brain development（Digitised adult brain atlas;Digitising the Fetal Brain Atlas）；Tomographic Anatomy and Neurodevelopment ；Neuroimaging；computational medicine；brain science； imaging of neuropsychiatric disorders； pathogenesis of neurodevelopmental and related diseases

Research Achievements:

(1) 2018.01-2021.12 Pre-natal development and visualisation of structural brain network groups, NSFC, 600,000 RMB

(2) 2016.01-2019.12 Early Morphogenesis of Cortical Folding in the Brain, National Natural Science Foundation of China, 650,000 Yuan

(3) 2014.01-2017.12 Imaging genetics of attention networks, National Natural Science Foundation of China, 700,000 RMB

(4) 2011.01-2013.12 Sexual dimorphism in prenatal development of the cerebral cortex, National Natural Science Foundation of China, 330,000 Yuan

(5) 2019.01-2022.12 Application and Industrialisation of Digital Human Research Results in Clinical Surgical Planning, Major Science and Technology Innovation Project of Shandong Province, 2 million yuan

(6) 2017.01-2019.12 4D Digital Brain Mapping Visualisation System for Chinese People, Shandong Key R&D Programme, 2 million RMB

(7) 2015.01-2017.12 R&D and Demonstration of High-Precision Digital Human Information Technology, Shandong Province Major Science and Technology Special Project, 2 million yuan.

(8) National Natural Science Foundation of China (NSFC) upper-level project, 31872802, Probabilistic mapping of white matter fibre connectivity in the brainstem, 2019/01-2022/12, 600,000 RMB, first place

(9) National Natural Science Foundation of China Young Science Fund Project, 81301280, Amphoteric Heteromorphism of White Matter in the Chinese Brain and Its Relationship with Cognitive Function, 2014/01-2016/12, 230,000 RMB, first place

(10) Effects of silencing α-synuclein on Parkinson's disease mice and its mechanism. Shandong Provincial Natural Science Foundation Youth Fund

Main Publications:

（1）Tian Mimi, Xu Feifei, Xia Qing, Tang Yuchun, Zhang Zhonghe, Lin Xiangtao, Meng Haiwei, Feng Lei,Liu Shuwei*. Morphological development of the human fetal striatum during the second trimester.Cerebral Cortex. 2022, 00:1-11.

（2）Wang Wenjun,YuQiaowen,Liang Wenjia, Xu Feifei,Li Zhuoran, Tang Yuchun*,Liu Shuwei*. Altered Cortical Microstructure in Preterm Infants at Term-equivalent Age Relative to Term-born Neonates.Cerebral Cortex, 2022, 1-12.

（3）Liang Wenjia,YuQiaowen,Wang Wenjun, Thijs Dhollander, Emmaneul Suluba,Li Zhuoran, Xu Feifei, Hu Yang, Tang Yuchun*,Liu Shuwei*. A comparative study of the superior longitudinal fasciculus subdivision between neonates and young adults.Brain Structure and Function, 2022.

（4）Wang Yu, Xu Feiei, Zhou Wenjuan, Hou Lanwei, Tang Yuchun,Liu Shuwei*. Morphological and hemispheric and sex differences of the anterior ascending ramus and the horizontal ascending ramus of the lateral sulcus.Brain Structure and Function. 2022.

（5）Zhao Xiaotian, Liang Wenjia, Wang Wenjun, Liu Hailan, Zhang Xiaolei, Liu Chengxin, Zhu Caiting, Cui Baoxia, Tang Yuchun*,Liu Shuwei*. Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development.Communications Biology, 2022. 5:1031.

（6）Tang Yuchun, Zhao Lu, Lou Yunxia, Shi Yonggang, Fang Rui, Lin Xiangtao, Liu Shuwei, Arthur Toga. Brain structure differences between Chinese and Caucasian cohorts: A comprehensive morphometry study. Human Brain Mapping, 2018, 39: 2147-2155.

（7）Tang Yuchun, Sun Wei, Arthur Toga, Ringman JM, Shi Yonggang. A probabilistic atlas of human brainstem pathways based on connectome imaging data. Neuroimage, 2018, 169: 227~239.

（8）Ge X, Shi Y, Li J, Zhang Z, Lin X, Zhan J, Ge H, Xu J, Yu Q, Leng Y, Teng G, Feng L, Meng H, Tang Y, Zang F, Toga AW, Liu S*. Development of the human fetal hippocampal formation during early second trimester. Neuroimage. 2015; 119:33-43.

（9）Feng L, Meng H, Wu F, Cheng B, He X, Wang X, Li Z, Liu S. Olfactory ensheathing cells conditioned medium prevented apoptosis induced by 6-OHDA in PC12 cells through modulation of intrinsic apoptotic pathways. Int J Dev Neurosci. 2008 May-Jun; 26(3-4):323-9.

（10）Wu F, Poon WS, Lu G, Wang A, Meng H, Feng L, Li Z, Liu S. Alpha-synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells. Brain Res. 2009; 1292: 173-9.

Facilities & Resources:

The main equipment includes SKC500 CNC milling machine, HN051 CNC sawing machine, Olympus BX63 fluorescence microscope system, SGI high-performance image workstations from Silicon Graphics of the United States, HP servers, and 50 high-performance computers from DELL of the United States.

Collaborations & Partnerships:

International Conferences

June 2011 Padua, Italy 11th European Congress of Clinical Anatomy

September 2009 Istanbul, Turkey 10th European Congress of Clinical Anatomy

May 2008 Tehran, Iran 5th Asia Pacific International Congress of Anatomists

December 2007 Qingdao, China First International Symposium on Tomographic Anatomy

Recent National Conferences

Nov 2011 Jinan Symposium on Tomographic Anatomy

April 2011, Qingdao The 6th National Symposium on Anatomy and Clinic (Head and Neck)

October 2010 Workshop on Archaeology of Human Bones, Jinan, China

August 2009 Yantai, China 2009 Annual Meeting of the Chinese Anatomical Society

April 2005 Workshop on Human Cross-Section Data Acquisition and Image Processing, Jinan, China

Recreational Activities:

Academic afternoon teas are held weekly, We don't just talk about academics, we talk about our life events. Some of the fun activities are held such as talk about the Ethics of Experiments (Declaration of Helsinki) together. Going to tourist attractions in Jinan is also a frequent event. the students and teachers play basketball and football together every week. Occasionally, we go to watch football matches on live. When new students arrive and graduates are sent off, we have a dinner and a chat half a year.

Other Features:

The feature of the lab is that the researchers and students of enrolment are not limited to medical students, and the intersection of medical and engineering research is the hallmark of our lab. Only through cross-collaboration of different disciplines can we continue to innovate.

Contact:

tyc@sdu.edu.cn